Defective UiO-66-NH2 (Zr) for Simultaneous Adsorption of Phosphate and Pb2+ for Hydrogen Peroxide Purification.

Removal of hetero ions from the hydrogen peroxide solution is a crucial step in purifying electronic-grade H2O2. Conventional adsorption materials are challenged to meet the need for the simultaneous adsorption of both anions and cations in solvents. UiO-66 (Zr) modified by acetic acid and amino group for simultaneous adsorption of phosphate and Pb2+ in H2O2 purification was fabricated in this work. The as-prepared defective UiO-66-NH2 (Zr) demonstrated a significant increase in specific surface area and porosity, along with more exposed sites for phosphate and Pb2+ adsorption. The adsorption capacity of De-UiO-66-NH2 for phosphate and Pb2+ in H2O2 solution was 52.28 mg g-1 and 35.4 mg g-1, which is 1.19 times and 1.88 times that of unmodified UiO-66 (Zr), respectively. The trace simultaneous adsorption with both 100 ppb phosphate and Pb2+ showed removal rates of 94.0% and 88.7%, respectively, confirming the practicality of MOF materials in the purification of electronic chemicals. This work highlights the potential of Zr-based MOFs as anionic and cationic simultaneous adsorbents for highly efficient purification of electronic-grade solvents.

Layered Topological Insulator MnBi2Te4 as a Cathode for a High Rate Performance Aqueous Zinc-Ion Battery.

Recently, the topological insulator MnBi2Te4 has aroused great attention owing to its exotic quantum phenomena and intriguing device applications, but the superior performances of MnBi2Te4 have not been researched in the field of electrochemistry. By theoretical calculations, it is found that MnBi2Te4 exhibits excellent Zn2+ storage and transport properties. Therefore, it is speculated that MnBi2Te4 has excellent electrochemical performance in zinc-ion batteries (ZIBs). In this research, MnBi2Te4 as a pioneer has been explored in ZIBs, showing surprising electrochemical properties. The MnBi2Te4 electrode displays a high average discharge specific capacity (264.8 mA h g-1 at 0.40 A g-1), a competitive cycle life (88.6% of initial capacity after 400 cycles at 4.00 A g-1), and an excellent rate performance (average capacity retention rate of 95.1% from 0.40 to 8.00 A g-1) owing to the fast ion transport of the conductive topological surface state and dissipationless channel of the edge state. Surprisingly, the quasi-solid-state (QSS) MnBi2Te4/Zn battery delivers excellent Zn2+ storage capability and possesses a capacity retention of 79.9% after 1000 cycles at 4.00 A g-1. In addition, the QSS MnBi2Te4/Zn battery can exhibit excellent performance and the GCD curves maintain stability without distortion deformation even at temperatures of 0 and 75 °C.

Metal-bonded perovskite lead hydride with phonon-mediated superconductivity exceeding 46 K under ambient pressure.

In the search for high-temperature superconductivity in hydrides, a plethora of multi-hydrogen superconductors have been theoretically predicted, and some have been synthesized experimentally under ultrahigh pressures of several hundred GPa. However, the impracticality of these high-pressure methods has been a persistent issue. In response, we propose a new approach to achieve high-temperature superconductivity under ambient pressure by implanting hydrogen into lead to create a stable few-hydrogen binary perovskite, Pb4H. This approach diverges from the popular design methodology of multi-hydrogen covalent high critical temperature (Tc) superconductors under ultrahigh pressure. By solving the anisotropic Migdal-Eliashberg equations, we demonstrate that perovskite Pb4H presents a phonon-mediated superconductivity exceeding 46 K with inclusion of spin-orbit coupling, which is six times higher than that of bulk Pb (7.22 K) and comparable to that of MgB2, the highestTcachieved experimentally at ambient pressure under the Bardeen, Cooper, and Schrieffer framework. The highTccan be attributed to the strong electron-phonon coupling strength of 2.45, which arises from hydrogen implantation in lead that induces several high-frequency optical phonon modes with a relatively large phonon linewidth resulting from H atom vibration. The metallic-bonding in perovskite Pb4H not only improves the structural stability but also guarantees better ductility than the widely investigated multi-hydrogen, iron-based and cuprate superconductors. These results suggest that there is potential for the exploration of new high-temperature superconductors under ambient pressure and may reignite interest in their experimental synthesis in the near future.

Wide-range soft anisotropic thermistor with a direct wireless radio frequency interface.

Temperature sensors are one of the most fundamental sensors and are found in industrial, environmental, and biomedical applications. The traditional approach of reading the resistive response of Positive Temperature Coefficient thermistors at DC hindered their adoption as wide-range temperature sensors. Here, we present a large-area thermistor, based on a flexible and stretchable short carbon fibre incorporated Polydimethylsiloxane composite, enabled by a radio frequency sensing interface. The radio frequency readout overcomes the decades-old sensing range limit of thermistors. The composite exhibits a resistance sensitivity over 1000 °C-1, while maintaining stability against bending (20,000 cycles) and stretching (1000 cycles). Leveraging its large-area processing, the anisotropic composite is used as a substrate for sub-6 GHz radio frequency components, where the thermistor-based microwave resonators achieve a wide temperature sensing range (30 to 205 °C) compared to reported flexible temperature sensors, and high sensitivity (3.2 MHz/°C) compared to radio frequency temperature sensors. Wireless sensing is demonstrated using a microstrip patch antenna based on a thermistor substrate, and a battery-less radio frequency identification tag. This radio frequency-based sensor readout technique could enable functional materials to be directly integrated in wireless sensing applications.

MXene-Integrated Perylene Anode with Ultra-Stable and Fast Ammonium-Ion Storage for Aqueous Micro Batteries.

The aqueous micro batteries (AMBs) are expected to be one of the most promising micro energy storage devices for its safe operation and cost-effectiveness. However, the performance of the AMBs is not satisfactory, which is attributed to strong interaction between metal ions and the electrode materials. Here, the first AMBs are developed with NH4 + as charge carrier. More importantly, to solve the low conductivity and the dissolution during the NH4 + intercalation/extraction problem of perylene material represented by perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA), the Ti3 C2 Tx MXene with high conductivity and polar surface terminals is introduced as a conductive skeleton (PTCDA/Ti3 C2 Tx MXene). Benefitting from this, the PTCDA/Ti3 C2 Tx MXene electrodes exhibit ultra-high cycle life and rate capability (74.31% after 10 000 galvanostatic chargedischarge (GCD) cycles, and 91.67 mAh g-1 at 15.0 A g-1 , i.e., capacity retention of 45.2% for a 30-fold increase in current density). More significantly, the AMBs with NH4 + as charge carrier and PTCDA/Ti3 C2 Tx MXene anode provide excellent energy density and power density, cycle life, and flexibility. This work will provide strategy for the development of NH4 + storage materials and the design of AMBs.

Pressure-Regulated Nanoconfined Channels for Highly Effective Mechanical-Electrical Conversion in Proton Battery-Type Self-Powered Pressure Sensor.

Battery-sensing-based all-in-one pressure sensors are generally successfully constructed by mimicking the information transfer of living organisms and the sensing behavior of human skin, possessing features such as low energy consumption and detection of low/high-frequency mechanical signals. To design high-performance all-in-one pressure sensors, a deeper understanding of the intrinsic mechanisms of such sensors is required. Here, a mechanical-electrical conversion mechanism based on pressure-modulated nanoconfined channels is proposed. Then, the mechanism of ion accelerated transport in graphene oxide (GO) nanoconfined channels under pressure is revealed by density functional theory (DFT) calculation. Based on this mechanism, a proton battery-type self-powered pressure sensor MoO3 /GO[CNF/Ca] /activated carbon (AC) is designed with an open-circuit voltage stabilization of 0.648 V, an ultrafast response/recovery time of 86.0 ms/93.0 ms, pressure detection ranges of up to 60.0 kPa, and excellent static/dynamic pressure response. In addition, the one-piece device design enables self-supply, miniaturization, and charge/discharge reuse, showing application potential in wearable electronics, health monitoring, and other fields.

M 2 FTrans: Modality-Masked Fusion Transformer for Incomplete Multi-Modality Brain Tumor Segmentation.

Brain tumor segmentation is a fundamental task and existing approaches usually rely on multi-modality magnetic resonance imaging (MRI) images for accurate segmentation. However, the common problem of missing/incomplete modalities in clinical practice would severely degrade their segmentation performance, and existing fusion strategies for incomplete multi-modality brain tumor segmentation are far from ideal. In this work, we propose a novel framework named M 2 FTrans to explore and fuse cross-modality features through modality-masked fusion transformers under various incomplete multi-modality settings. Considering vanilla self-attention is sensitive to missing tokens/inputs, both learnable fusion tokens and masked self-attention are introduced to stably build long-range dependency across modalities while being more flexible to learn from incomplete modalities. In addition, to avoid being biased toward certain dominant modalities, modality-specific features are further re-weighted through spatial weight attention and channel- wise fusion transformers for feature redundancy reduction and modality re-balancing. In this way, the fusion strategy in M 2 FTrans is more robust to missing modalities. Experimental results on the widely-used BraTS2018, BraTS2020, and BraTS2021 datasets demonstrate the effectiveness of M 2 FTrans, outperforming the state-of-the-art approaches with large margins under various incomplete modalities for brain tumor segmentation. Code is available at https://github.com/Jun-Jie-Shi/M2FTrans.

Damped two-axis axially collocated flexure hinge.

Broadband motion control in flexure-based stages can benefit from passive damping enhancement at their flexible structures. This paper develops a damped two-axis axially collocated (2-AC) flexure hinge with damping-enabling hybrid inserts and analytically derives its loss factor model based on hybrid (empirical and analytical) compliance modeling and shearing damping modeling. The analytical loss factor model is verified by finite element analysis. It is seen that the geometric parameters of the diameter and slope angle of the insert are sensitive to the hinge's loss factor based on the theoretical loss factor model, especially in low-frequency and resonant zone. The actual experiments and finite element simulation indicate that embedding the hybrid inserts into the 2-AC flexure hinge can improve the damping performance of the hinge.

Few-Hydrogen High-Tc Superconductivity in (Be4)2H Nanosuperlattice with Promising Ductility under Ambient Pressure.

The multi-hydrogen lanthanum hydride LaH10 is well recognized as having the highest critical temperature (Tc) of 250-260 K under unrealistically ultrahigh pressures of about 170-200 GPa. Here, we propose a novel idea for designing a new ambient-pressure high-Tc superconductor by inserting a hexagonal H-monolayer into two close-packed Be monolayers to form a new and stable few-hydrogen metal-bonded layered beryllium hydride (Be4)2H nanosuperlattice, with better ductility than multi-hydrogen, cuprate, and iron-based superconductors, completely contrary to the conventional design strategy for multi-hydrogen covalent high-Tc superconductors with poor ductility at several hundred GPa. We find that (Be4)2H is a phonon-mediated Eliashberg superconductor with a large electron-phonon coupling constant of 1.41 and a high Tc of 84-72 K with Coulomb repulsion pseudopotential µ* = 0.07-0.13. Importantly, (Be4)2H is the only new high-Tc superconductor and fills the gap in the absence of ambient-pressure superconductors around the liquid-nitrogen temperature with good ductility, which is highly beneficial for practical applications.

Enhancement for phonon-mediated superconductivity up to 37 K in few-hydrogen metal-bonded layered magnesium hydride under atmospheric pressure.

The discovery of superconductivity in layered MgB2 has renewed interest in the search for high-temperature conventional superconductors, leading to the synthesis of numerous hydrogen-dominated materials with high critical temperatures (Tc) under high pressures. However, achieving a high-Tc superconductor under ambient pressure remains a challenging goal. In this study, we propose a novel approach to realize a high-temperature superconductor under ambient pressure by introducing a hexagonal H monolayer into the hexagonal close-packed magnesium lattice, resulting in a new and stable few-hydrogen metal-bonded layered magnesium hydride (Mg4)2H1. This compound exhibits superior ductility compared to multi-hydrogen, cuprate, and iron-based superconductors due to its metallic bonding. Our unconventional strategy diverges from the conventional design principles used in hydrogen-dominated covalent high-temperature superconductors. Using anisotropic Migdal-Eliashberg equations, we demonstrate that the stable (Mg4)2H1 compound is a typical phonon-mediated superconductor, characterized by strong electron-phonon coupling and an excellent Tc of 37 K under ambient conditions, comparable to that of MgB2. Our findings not only present a new pathway for exploring high-temperature superconductors but also provide valuable insights for future experimental synthesis endeavors.

An Internal Defect Detection Algorithm for Concrete Blocks Based on Local Mean Decomposition-Singular Value Decomposition and Weighted Spatial-Spectral Entropy.

Within the scope of concrete internal defect detection via laser Doppler vibrometry (LDV), the acquired signals frequently suffer from low signal-to-noise ratios (SNR) due to the heterogeneity of the concrete's material properties and its rough surface structure. Consequently, these factors make the defect signal characteristics challenging to discern precisely. In response to this challenge, we propose an internal defect detection algorithm that incorporates local mean decomposition-singular value decomposition (LMD-SVD) and weighted spatial-spectral entropy (WSSE). Initially, the LDV vibration signal undergoes denoising via LMD and the SVD algorithms to reduce noise interference. Subsequently, the distribution of each frequency in the scan plane is analyzed utilizing the WSSE algorithm. Since the vibrational energy of the frequencies caused by the defect resonance is concentrated in the defect region, its energy distribution in the scan plane is non-uniform, resulting in a significant difference between the defect resonance frequencies' SSE values and the other frequencies' SSE values. This feature is used to estimate the resonant frequencies of internal defects. Ultimately, the defects are characterized based on the modal vibration patterns of the defect resonant frequencies. Tests were performed on two concrete blocks with simulated cavity defects, using an ultrasonic transducer as the excitation device to generate ultrasonic vibrations directly from the back of the blocks and applying an LDV as the acquisition device to collect vibration signals from their front sides. The results demonstrate the algorithm's capacity to effectively pinpoint the information on the location and shape of shallow defects within the concrete, underscoring its practical significance for concrete internal defect detection in practical engineering scenarios.

Identification and evaluation of circulating exosomal miRNAs for the diagnosis of postmenopausal osteoporosis.

BACKGROUND: Postmenopausal osteoporosis (PMOP) is a common condition that leads to a loss of bone density and an increased risk of fractures in women. Recent evidence suggests that exosomal miRNAs are involved in regulating bone development and osteogenesis. However, exosomal miRNAs as biomarkers for PMOP diagnosis have not been systematically evaluated. In this study, we aim to identify PMOP-associated circulating exosomal miRNAs and evaluate their diagnostic performance. METHODS: We performed next-generation sequencing and bioinformatics analysis of plasma exosomal miRNAs from 12 PMOP patients and 12 non-osteoporosis controls to identify PMOP-associated exosomal miRNAs, and then validated them in an independent natural community cohort with 26 PMOP patients and 21 non-osteoporosis controls. Exosomes were isolated with the size exclusion chromatography method from the plasma of elder postmenopausal women. The plasma exosomal miRNA profiles were characterized in PMOP paired with controls with next-generation sequencing. Potential plasma exosomal miRNAs were validated by qRT-PCR in the validation cohort, and their performance in diagnosing PMOP was systematically evaluated with the receiver operating characteristic curve. RESULTS: Twenty-seven miRNAs were identified as differentially expressed in PMOP versus controls in sequencing data, of which six exosomal miRNAs (miR-196-5p, miR-224-5p, miR320d, miR-34a-5p, miR-9-5p, and miR-98-5p) were confirmed to be differentially expressed in PMOP patients by qRT-PCR in the validation cohort. The three miRNAs combination (miR-34a-5p + miR-9-5p + miR-98-5p) demonstrated the best diagnostic performance, with an AUC = 0.734. In addition, the number of pregnancies was found to be an independent risk factor that can improve the performance of exosomal miRNAs in diagnosing PMOP. CONCLUSIONS: These results suggested that the plasma exosomal miRNAs had the potential to serve as noninvasive diagnostic biomarkers for PMOP.

Red mud-derived iron carbon catalyst for the removal of organic pollutants in wastewater.

In order to reduce the environmental hazards of red mud (RM) and realize its resource utilization, in this study, RM-based iron-carbon micro-electrolysis material (RM-MEM) were prepared by a carbothermal reduction process using RM as raw material. The influence of the preparation conditions on the phase transformation and structural characteristics of the RM-MEM were investigated during the reduction process. The ability of RM-MEM to remove organic pollutants from wastewater was evaluated. The results showed that RM-MEM prepared at a reduction temperature of 1100 °C, a reduction time of 50 min and a coal dosage of 50% had the best removal effect for the degradation of methylene blue (MB). When the initial MB concentration was 20 mg L-1, the amount of RM-MEM material was 4 g L-1, the initial pH was 7, and the degradation efficiency reached 99.75% after 60 min. When RM-MEM is split into carbon free and iron free parts for use, the degradation effect becomes worse. Compared to other materials, RM-MEM has lower cost and better degradation. X-ray diffraction (XRD) analysis showed that hematite was transformed to zero-valent iron with the increase in the roasting temperature. Scanning electron microscopy (SEM) and energy spectroscopy (EDS) analysis showed that micron-sized ZVI particles were formed in the RM-MEM, and increasing the carbon thermal reduction temperature was beneficial to the growth of zero-valent iron particles.

Establishing extended pluripotent stem cells from human urine cells.

BACKGROUND: Extended pluripotent stem cells (EPSCs) can contribute to both embryonic and trophectoderm-derived extraembryonic tissues. Therefore, EPSCs have great application significance for both research and industry. However, generating EPSCs from human somatic cells remains inefficient and cumbersome. RESULTS: In this study, we established a novel and robust EPSCs culture medium OCM175 with defined and optimized ingredients. Our OCM175 medium contains optimized concentration of L-selenium-methylcysteine as a source of selenium and ROCK inhibitors to maintain the single cell passaging ability of pluripotent stem cells. We also used Matrigel or the combination of laminin 511 and laminin 521(1:1) to bypass the requirement of feeder cells. With OCM175 medium, we successfully converted integration-free iPSCs from easily available human Urine-Derived Cells (hUC-iPSCs) into EPSCs (O-IPSCs). We showed that our O-IPSCs have the ability to form both intra- and extra- embryonic chimerism, and could contribute to the trophoblast ectoderm lineage and three germ layer cell lineages. CONCLUSIONS: In conclusion, our novel OCM175 culture medium has defined, optimized ingredients, which enables efficient generation of EPSCs in a feeder free manner. With the robust chimeric and differentiation potential, we believe that this system provides a solid basis to improve the application of EPSCs in regenerative medicine.

Thiol-Aldehyde Polycondensation for Bio-based Adaptable and Degradable Phenolic Polymers.

Designing sustainable materials with tunable mechanical properties, intrinsic degradability, and recyclability from renewable biomass through a mild process has become vital in polymer science. Traditional phenolic resins are generally considered to be not degradable or recyclable. Here we report the design and synthesis of linear and network structured phenolic polymers using facile polycondensation between natural aldehyde-bearing phenolic compounds and polymercaptans. Linear phenolic products are amorphous with Tg between -9 °C and 12 °C. Cross-linked networks from vanillin and its di-aldehyde derivative exhibited excellent mechanical strength between 6-64 MPa. The connecting dithioacetals are associatively adaptable strong bonds and susceptible to degradation in oxidative conditions to regenerate vanillin. These results highlight the potential of biobased sustainable phenolic polymers with recyclability and selective degradation, as a complement to the traditional phenol-formaldehyde resins.

Development of Marker Recycling Systems for Sequential Genetic Manipulation in Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7.

Marine-derived fungi are emerging as prolific workhorses of structurally novel natural products (NPs) with diverse bioactivities. However, the limitation of available selection markers hampers the exploration of cryptic NPs. Recyclable markers are therefore valuable assets in genetic engineering programs for awaking silent SM clusters. Here, both pyrG and amdS-based recyclable marker cassettes were established and successfully applied in marine-derived fungi Aspergillus sp. SCSIO SX7S7 and Spiromastix sp. SCSIO F190, respectively. Using pyrG recyclable marker, a markerless 7S7-∆depH strain with a simplified HPLC background was built by inactivating a polyketide synthase (PKS) gene depH and looping out the pyrG recyclable marker after depH deletion. Meanwhile, an amdS recyclable marker system was also developed to help strains that are difficult to use pyrG marker. By employing the amdS marker, a backbone gene spm11 responsible for one major product of Spiromastix sp. SCSIO F190 was inactivated, and the amdS marker was excised after using, generating a relatively clean F190-∆spm11 strain for further activation of novel NPs. The collection of two different recycle markers will guarantee flexible application in marine-derived fungi with different genetic backgrounds, enabling the exploitation of novel structures in various fungi species with different genome mining strategies.

Forecast and verification of the active compounds and latent targets of Guyuan decoction in treating frequently relapsing nephrotic syndrome based on network pharmacology.

BACKGROUND: Our study majorly utilizes network pharmacology combined with molecular docking to explore the latent active components and associated pivotal targets of Guyuan Decoction (GYD) in the treatment of frequently relapsing nephrotic syndrome (FRNS). METHODS: All active components and latent targets of GYD were retrieved from TCMSP database. The target genes for FRNS in our research were obtained from the GeneCards database. The drug-compounds-disease-targets (D-C-D-T) network was established using Cytoscape 3.7.1. STRING database was applied to observe the protein interaction. Pathway enrichment analyses (GO and KEGG) were conducted in R software. Moreover, molecular docking was employed to further validate the binding activity. MPC-5 cells were treated with adriamycin to mimic FRNS in vitro and to determine the effects of luteolin on modeled cells. RESULTS: A total of 181 active components and 186 target genes of GYD were identified. Meanwhile, 518 targets related to FRNS were also revealed. Based on the intersection using a Venn diagram, 51 common latent targets were recognized to be associated with active ingredients and FRNS. Additionally, we identified the biological processes and signaling pathways involved in the action of these targets. Molecular docking analyses illustrated that AKT1 and CASP3 interacted with luteolin, wogonin, and kaempferol, respectively. Moreover, luteolin treatment enhanced the viability but inhibited the apoptosis of adriamycin-treated MPC-5 cells via regulating AKT1 and CASP3. CONCLUSION: Our study forecasts the active compounds, latent targets, and molecular mechanisms of GYD in FRNS, which helps us to understand the action mechanism of GYD in FRNS comprehensive treatment.

MALDI Imaging Assisted Discovery of a Di-O-glycosyltransferase from Platycodon grandiflorum Root.

A matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) assisted genome mining strategy was developed for the discovery of glycosyltransferase (GT) from the root of Platycodon grandiflorum. A di-O-glycosyltransferase PgGT1 was discovered and characterized that is capable of catalyzing platycoside E (PE) synthesis through the attachment of two ß-1,6-linked glucosyl residues sequentially to the glucosyl residue at the C3 position of platycodin D (PD). Although UDP-glucose is the preferred sugar donor for PgGT1, it could also utilize UDP-xylose and UDP-N-acetylglucosamine as weak donors. Residues S273, E274, and H350 played important roles in stabilizing the glucose donor and positioning the glucose in the optimal orientation for the glycosylation reaction. This study clarified two key steps involved in the biosynthetic pathway of PE and could greatly contribute to improving its industrial biotransformation.

An Air-Rechargeable Zn Battery Enabled by Organic-Inorganic Hybrid Cathode.

Self-charging power systems collecting energy harvesting technology and batteries are attracting extensive attention. To solve the disadvantages of the traditional integrated system, such as highly dependent on energy supply and complex structure, an air-rechargeable Zn battery based on MoS2/PANI cathode is reported. Benefited from the excellent conductivity desolvation shield of PANI, the MoS2/PANI cathode exhibits ultra-high capacity (304.98 mAh g-1 in N2 and 351.25 mAh g-1 in air). In particular, this battery has the ability to collect, convert and store energy simultaneously by an air-rechargeable process of the spontaneous redox reaction between the discharged cathode and O2 from air. The air-rechargeable Zn batteries display a high open-circuit voltage (1.15 V), an unforgettable discharge capacity (316.09 mAh g-1 and the air-rechargeable depth is 89.99%) and good air-recharging stability (291.22 mAh g-1 after 50 air recharging/galvanostatic current discharge cycle). Most importantly, both our quasi-solid zinc ion batteries and batteries modules have excellent performance and practicability. This work will provide a promising research direction for the material design and device assembly of the next-generation self-powered system.